We need to establish regenerative and healthy environments. In the last 3 decades, we have realized numerous projects to improve the livability of cities and regions in co-creation with residents. The experiences gained from our work are the basis for further projects, as well as teachings and research. These resulted in arising new tasks which require dedication to the development of regenerative areas that support healthy conditions. To achieve such environments and gain impacts in complex systems, the will and ability of interdisciplinary cooperation is crucial. In consequences, living systems where biophilia and biodiversity are nourished will arise.